Kaist

AI Opens a New Era in Medical Science and Bio​

< (From left) KAIST Professors Yoonjae Choi, Tae-Kyun Kim, Jong Chul Ye, Hyunwoo Kim, Seunghoon Hong, Sang Yup Lee >    KAIST announced on the 14th of November that it has been selected as a major participating institution in the 'Lunit Consortium' for the 'AI Specialized Foundation Model Development Project' supervised by the Ministry of Science and ICT, and has officially started developing an AI foundation model for the medical science and bio fields. Through this project, KAIST plans to develop an 'AI Foundation Model Specialized for Medical Science' that encompasses the entire lifecycle of bio and medical data, and lead the creation of an AI based life science innovation ecosystem. The 'Lunit Consortium' includes 7 companies-Lunit, Trillion Labs, Kakao Healthcare, Igenscience, SK Biopharm, and Rebellion-along with 9 medical and research institutions, including KAIST, Seoul National University, NYU, National Health Insurance Service Ilsan Hospital, and Yonsei Severance Hospital. This consortium will be supported by 256 state of the art B200 GPUs to build and demonstrate a 'Chain of Evidence-Based Full-Cycle Medical Science AI Model', an AI system that connects and analyzes medical data from beginning to end, and a 'Multi-Agent Service', a system where multiple AIs collaborate to perform diagnosis and prediction. KAIST's participation in this project involves a joint research team formed by professors from the School of Computing and the Kim Jaechul Graduate School of AI. Professors Yoonjae Choi, Tae-Kyun Kim, Jong Chul Ye, Hyunwoo Kim, and Seunghoon Hong will serve as the research team, and Vice President for Research  Sang Yup Lee will take on an advisory role. The research team is not merely collecting data but they are establishing a strategy (L1~L7 stages) to precisely process and systematically manage medical and life science data so that the AI can actually learn and utilize it. Through this, they plan to develop and verify an AI model that connects and analyzes diverse life science data, including medical information, gene/protein data, and new drug candidates. The data the research team aims to integrate includes a wide range from language to actual patient treatment information. Specifically, L1 represents language data, L2 is the structure of molecules, L3 is proteins and antibodies, L4 is omics data encompassing genetic and protein information, L5 is drug information, L6 is medical science research and clinical data, and L7 is real-world clinical data obtained from actual hospitals. In essence, the data handled by the AI connects everything from speech and text to molecules, proteins, drugs, clinical research, and actual patient treatment information. < The process of training AI by viewing X ray images and doctor's interpretation (text) together (MedViLL from Professor Jae-Yoon Choi' s lab) >  Vice President Sang Yup Lee is a world-renowned scholar in the fields of synthetic biology and systems metabolic engineering, leading the establishment of a bio manufacturing platform and policy advice through the convergence of life science, engineering, and AI. He advises on the analysis of life information (omics) such as genes and proteins and designs a feedback system for verifying experimental results, supporting the Korean-developed medical AI model to secure international reliability and competitiveness. Vice President Lee stated, "AI technology is breaking down the boundaries of life science and engineering, creating a new paradigm for knowledge creation," adding, "KAIST will utilize full cycle medical science data to accelerate the era where AI uncovers the causes of diseases and predicts treatments." KAIST President Kwang Hyung Lee said, "KAIST will contribute to creating an AI-based life science innovation ecosystem, lead the innovation of national strategic industries through world-class AI-bio convergence research, and drive the progress of human health and science and technology." The model developed in the Lunit Consortium will be released as an Open License for commercial use, and is expected to expand into various medical and healthcare services such as national health chatbots. With this participation, KAIST plans to strengthen research on AI-based life science data infrastructure establishment, medical AI standardization, and AI ethics and policy advice, leading the AI transition of national bio and medical science research.      

KAIST Develops Wearable Ultrasound Sensor Enabling..

<(From Left) Professor Hyunjoo Jenny Lee, Dr.Sang-Mok Lee, Ph.D candidate Xiaojia Liang>       Conventional wearable ultrasound sensors have been limited by low power output and poor structural stability, making them unsuitable for high-resolution imaging or therapeutic applications. A KAIST research team has now overcome these challenges by developing a flexible ultrasound sensor with statically adjustable curvature. This breakthrough opens new possibilities for wearable medical devices that can capture precise, body-conforming images and perform noninvasive treatments using ultrasound energy. KAIST (President Kwang Hyung Lee) announced on November 12 that a research team led by Professor Hyunjoo Jenny Lee from the School of Electrical Engineering developed a “flex-to-rigid (FTR)” capacitive micromachined ultrasonic transducer (CMUT) capable of transitioning freely between flexibility and rigidity using a semiconductor wafer process (MEMS). The team incorporated a low-melting-point alloy (LMPA) inside the device. When an electric current is applied, the metal melts, allowing the structure to deform freely; upon cooling, it solidifies again, fixing the sensor into the desired curved shape. Conventional polymer-membrane-based CMUTs have suffered from a low elastic modulus, resulting in insufficient acoustic power and blurred focal points during vibration. They have also lacked curvature control, limiting precise focusing on target regions. Professor Lee’s team designed an FTR structure that combines a rigid silicon substrate with a flexible elastomer bridge, achieving both high output performance and mechanical flexibility. The embedded LMPA enables dynamic adjustment and fixation of the transducer’s shape by toggling between solid and liquid states through electrical control. As a result, the new sensor can automatically focus ultrasound on a specific region according to its curvature—without requiring separate beamforming electronics—and maintains stable electrical and acoustic performance even after repeated bending. The device’s acoustic output reaches the level of low-intensity focused ultrasound (LIFU), which can gently stimulate tissues to induce therapeutic effects without causing damage. Experiments on animal models demonstrated that noninvasive spleen stimulation reduced inflammation and improved mobility in arthritis models. In the future, the team plans to extend this technology to a two-dimensional (2D) array structure—arranging multiple sensors in a grid—to enable simultaneous high-resolution ultrasound imaging and therapeutic applications, paving the way for a new generation of smart medical systems. Because the technology is compatible with semiconductor fabrication processes, it can be mass-produced and adapted for wearable and home-use ultrasound systems. This study was conducted by Sang-Mok Lee, Xiaojia Liang (co–first authors), and their collaborators under the supervision of Professor Hyunjoo Jenny Lee. The results were published online on October 23 in npj Flexible Electronics (Impact Factor: 15.5). Paper title: “Flexible ultrasound transducer array with statically adjustable curvature for anti-inflammatory treatment” DOI: [10.1038/s41528-025-00484-7] The research was supported by the Bio & Medical Technology Development Program (Brain Science Convergence Research Program) of the Ministry of Science and ICT (MSIT) and the Korea Medical Device Development Fund, a multi-ministerial R&D initiative.      

Automatic C to Rust Translation Technology Gains G..

<(From Left) Professor Sukyoung Ryu, Researcher  Jaemin Hong>     As the C language, which forms the basis of critical global software like operating systems, faces security limitations, KAIST's research team is pioneering core original technology research for the accurate automatic conversion to Rust to replace it. By proving the mathematical correctness of the conversion, a limitation of existing Artificial Intelligence (LLM) methods, and solving C language security issues through automatic conversion to Rust, they presented a new direction and vision for future software security research. This work has been selected as the cover story for CACM, the world's highest-authority academic journal, thereby demonstrating KAIST's global research leadership in the field of computer science. KAIST announced on the 9th of November that the paper by Professor Sukyoung Ryu's research team (Programming Language Research Group) from the School of Computing was selected as the cover story for the November issue of CACM (Communications of the ACM), the highest authority academic journal published by ACM (Association for Computing Machinery), the world's largest computer society. <Photo of the Paper Selected for the Cover of Communications of the ACM> This paper comprehensively addresses the technology developed by Professor Sukyoung Ryu's research team for the automatic conversion of C language to Rust, and it received high acclaim from the international research community for presenting the technical vision and academic direction this research should pursue in the future. The C language has been widely used in the industry since the 1970s, but its structural limitations have continuously caused severe bugs and security vulnerabilities. Rust, on the other hand, is a secure programming language developed since 2015, used in the development of operating systems and web browsers, and has the characteristic of being able to detect and prevent bugs before program execution. The US White House recommended discontinuing the use of C language in a technology report released in February 2024, and the Defense Advanced Research Projects Agency (DARPA) also explicitly stated that Rust is the core alternative for resolving C language security issues by promoting a project to develop technology for the automatic conversion of C code to Rust. Professor Sukyoung Ryu's research team proactively raised the issues of C language safety and the importance of automatic conversion even before these movements began in earnest, and they have continuously developed core related technologies. In May 2023, the research team presented the Mutex conversion technology (necessary for program synchronization) at ICSE (International Conference on Software Eng), the top authority conference in software engineering. In June 2024, they presented the Output Parameter conversion technology (used for result delivery) at PLDI (Programming Language Design and Implementation), the top conference in programming languages, and in October of the same year, they presented the Union conversion technology (for storing diverse data together) at ASE (Automated Software Eng), the representative conference in software automation. These three studies are all "world-first" achievements presented at top-tier international academic conferences, successfully implementing automatic conversion technology for each feature with high completeness. Since 2023, the research team has consistently published papers in CACM every year, establishing themselves as global leading researchers who consistently solve important and challenging problems worldwide. This paper was published in CACM (Communications of the ACM) on October 24, with Dr. Jaemin Hong (Postdoctoral Research Fellow at KAIST Information and Electronics Research Institute) as the first author. ※Paper Title: Automatically Translating C to Rust, DOI: https://doi.org/10.1145/3737696 Dr. Jaemin Hong stated, "The conversion technology we developed is an original technology based on programming language theory, and its biggest strength is that we can logically prove the 'correctness' of the conversion." He added, "While most research relies on Large Language Models (LLMs), our technology can mathematically guarantee the correctness of the conversion." Dr. Hong is scheduled to be appointed as an Assistant Professor in the Computer Science Department at UNIST starting in March 2025. Furthermore, Professor Ryu's research team has four papers accepted for presentation at ASE 2025, the highest-authority conference in software engineering, including C→Rust conversion technology. These papers, in addition to automatic conversion technology, cover various cutting-edge software engineering fields and are receiving high international acclaim. They include: technology to verify whether quantum computer programs operate correctly, 'WEST' technology that automatically checks the correctness of WebAssembly programs (technology for fast and efficient program execution on the web) and creates tests for them, and technology that automatically simplifies complex WebAssembly code to quickly find errors. Among these, the WEST paper received the Distinguished Paper Award. This research was supported by the Leading Research Center/Mid-career Researcher Support Program of the National Research Foundation of Korea, the Institute of Information & Communications Technology Planning & Evaluation (IITP), and Samsung Electronics.  

Professor Sang Yup Lee Selected as IETI ＇Laureate ..

  <Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering>       Professor Sang Yup Lee of KAIST Department of Chemical and Biomolecular Engineering has been selected as a 'Laureate Distinguished Fellow,' the highest rank of fellow, by the International Engineering and Technology Institute (IETI). Professor Lee is a globally renowned biotechnologist who has been leading research on the sustainable production of bio-based chemicals, and he received the 'ENI Award' in 2018. With this selection, he stands shoulder-to-shoulder with the world's top scholars, including recipients of the Nobel, Fields, and Turing Prizes. IETI is an international academic organization established in Hong Kong in 2015 to promote innovation and international cooperation in the fields of engineering, technology, and science. Each year, the institute selects researchers with significant academic influence worldwide and appoints them into three grades: Laureate Distinguished Fellow, Distinguished Fellow, and Fellow. Professor Lee has been named to the most prestigious grade among these. <IETI 2025 Fellow Selection Photo>     A total of 70 new fellows were selected in 2025. Among them, 14 individuals were named Laureate Distinguished Fellows, which includes recipients of top honors such as the Nobel, Fields, and Turing Prizes. Besides Professor Lee, this group includes Dudley Herschbach of Harvard University (Nobel Prize in Chemistry), Vint Cerf of Google (Turing Award), and Shigefumi Mori of Kyoto University (Fields Medal). IETI stated that the selection process involved a rigorous five-step procedure: nomination, qualification review, document screening, expert voting, and final evaluation. It also expressed hope that the newly appointed fellows will demonstrate academic leadership in their respective research fields and contribute to global scientific and technological innovation and the promotion of international cooperation.

KAIST＇s ＇FluidGPT＇ Wins Grand Prize at the 2025 AI..

<Commemorative Photo After Winning at the 2025 AI Champions Award Ceremony>   The era has begun where an AI assistant goes beyond simple conversation to directly view the screen, make decisions, and complete tasks such as hailing a taxi or booking an SRT ticket. KAIST (President Kwang Hyung Lee) announced on the 6th that the AutoPhone Team (Fluidez, KAIST, Korea University, Sungkyunkwan University), led by Professor Insik Shin (CEO of Fluidez Co., Ltd.) of the School of Computing, was selected as the inaugural AI Champion (1st place) in the '2025 Artificial Intelligence Champion (AI Champion) Competition,' hosted by the Ministry of Science and ICT. This competition is the nation's largest AI technology contest, comprehensively evaluating the innovativeness, social impact, and commercial potential of AI technology. With 630 teams participating nationwide, the AutoPhone Team claimed the top honor and will receive 3 billion Korean won in research and development funding. The technology developed by the AutoPhone Team, 'FluidGPT,' is a fully autonomous AI agent that understands a user's voice command and enables the smartphone to independently run apps, click, input, and even complete payments. For example, when a user says, "Book an SRT ticket from Seoul Station to Busan," or "Call a taxi," FluidGPT opens the actual app and sequentially performs the necessary steps to complete the request. The core of this technology is its 'Non-Invasive (API-Free)' structure. Previously, calling a taxi using an app required directly connecting to the app's internal system (API communication) through the taxi app's API. In contrast, this technology does not modify the existing app's code or link an API. Instead, the AI directly recognizes and operates the screen (UI), acquiring the ability to use the smartphone just like a human. As a result, FluidGPT presents a new paradigm—"AI that sees, judges, and moves a hand on behalf of a person"—and is evaluated as a core technology that will usher in the 'AI Phone Era.' FluidGPT moves beyond simple voice assistance to implement the concept of 'Agentic AI' (Action-Oriented Artificial Intelligence), where the AI directly views the screen, makes decisions, and takes action. As a fully action-oriented system, the AI clicks app buttons, fills in input fields, and references data to autonomously achieve the user's objective, foreshadowing an innovation in how smartphones are used. Professor In-sik Shin of the School of Computing shared his thoughts, stating, "AI is now evolving from conversation to action. FluidGPT is a technology that understands the user's words and autonomously executes actual apps, and it will be the starting point of the 'AI Phone Era.' The AutoPhone Team possesses world-class research capabilities, and we will contribute to the widespread adoption of AI services that everyone can easily use." KAIST President Kwang Hyung Lee remarked, "This achievement is a representative example that demonstrates KAIST's vision for AI convergence," adding, "AI technology is entering the daily lives of citizens and leading a new wave of innovation." He further added, "KAIST will continue to lead research in future core technologies such as AI and semiconductors to bolster national competitiveness."      

IEEE President Professor Kramer Holds Special Lect..

Kathleen A. Kramer, President of the IEEE (Institute of Electrical and Electronics Engineers), the world's largest technical professional organization dedicated to electrical and electronic technology, visited our university on the 30th and delivered a special lecture under the theme, 'Drawing the Future of Artificial Intelligence Together.' < IEEE Leadership and KAIST EE Meeting KITIS Director (Sung-Hyun Hong), KAIST EE Professors (Joonwoo Bae), (Ian Oakley), (Hye-Won Jeong), (Chang-Shik Choi), (Dong-Soo Han), Head of EE Department (Seunghyup Yoo), IEEE President (Kathleen A. Kramer), IEEE Senior Sales Director (Francis Staples), IEEE Regional Manager for APAC (Ira Tan), KAIST EE Professor (Hee-Jin Ahn), Head of Semiconductor System Engineering Department (Sung-Hwan Cho)> Standing at the colloquium podium by invitation of the Department of Electrical Engineering (Head: Seung-Hyup Yoo), President Kramer emphasized based on IEEE's core vision, 'Advancing Technology for Humanity,' that "Artificial Intelligence (AI) is no longer a concept of the distant future; it has become a technology that is transforming human lives at the center of innovation." < Photo of IEEE President's KAIST EE Colloquium Lecture > She further added, "Technology must advance with human values at its core, and AI based on ethics and inclusiveness can lead to true innovation," sharing her insights on the direction of AI development and the social responsibility of technology. Seung-Hyup Yoo, Head of the Department of Electrical Engineering, stated, "We expect President Kramer's visit to be a stepping stone that will not only widely promote our department's capabilities in advanced fields such as AI, semiconductors, signal processing, and robotics to the international academic community but also strengthen cooperation in various ways." < Tea Meeting with the IEEE Leadership and the Vice Presidents . KITIS Director (Sung-Hyun Hong), IEEE Senior Sales Director (Francis Staples), IEEE President (Kathleen A. Kramer), KAIST Executive Vice President for Research (Sang Yup Lee), Head of EE Department (Seunghyup Yoo), IEEE Regional Manager for APAC (Ira Tan)> Meanwhile, prior to the lecture, President Kramer paid a courtesy visit to Sang-Yup Lee, KAIST Executive Vice President for Research, and reaffirmed the commitment of both organizations to advancing sustainable technology and building an ethical and inclusive research ecosystem to contribute to a better life for humanity.    

KAIST Develops Room-Temperature 3D Printing Techno..

  <(From Left) Professor Ji Tae Kim of the Department of Mechanical Engineering, Professor Soong Ju Oh of Korea University and Professor Tianshuo Zhao of the University of Hong Kong> The “electronic eyes” technology that can recognize objects even in darkness has taken a step forward. Infrared sensors, which act as the “seeing” component in devices such as LiDAR for autonomous vehicles, 3D face recognition systems in smartphones, and wearable healthcare devices, are regarded as key components in next-generation electronics. Now, a research team at KAIST and their collaborators have developed the world’s first room-temperature 3D printing technology that can fabricate miniature infrared sensors in any desired shape and size. KAIST (President Kwang Hyung Lee) announced on the 3rd of November that the research team led by Professor Ji Tae Kim of the Department of Mechanical Engineering, in collaboration with Professor Soong Ju Oh of Korea University and Professor Tianshuo Zhao of the University of Hong Kong, has developed a 3D printing technique capable of fabricating ultra-small infrared sensors—smaller than 10 micrometers (µm)—in customized shapes and sizes at room temperature. Infrared sensors convert invisible infrared signals into electrical signals and serve as essential components in realizing future electronic technologies such as robotic vision. Accordingly, miniaturization, weight reduction, and flexible form-factor design have become increasingly important. Conventional semiconductor fabrication processes were well suited for mass production but struggled to adapt flexibly to rapidly changing technological demands. They also required high-temperature processing, which limited material choices and consumed large amounts of energy. To overcome these challenges, the research team developed an ultra-precise 3D printing process that uses metal, semiconductor, and insulator materials in the form of liquid nanocrystal inks, stacking them layer by layer within a single printing platform. This method enables direct fabrication of core components of infrared sensors at room temperature, allowing for the realization of customized miniature sensors of various shapes and sizes. Particularly, the researchers achieved excellent electrical performance without the need for high-temperature annealing by applying a “ligand-exchange” process, where insulating molecules on the surface of nanoparticles are replaced with conductive ones. As a result, the team successfully fabricated ultra-small infrared sensors measuring less than one-tenth the thickness of a human hair (under 10 µm). <Figure 1. 3D printing of infrared sensors.a. Room-temperature printing process for the electrodes and photoactive layer that make up the infrared sensor.b. Structure and chemical composition of the printed infrared microsensor. c.Printed infrared sensor micropixel array.>   Professor Ji Tae Kim commented, “The developed 3D printing technology not only advances the miniaturization and lightweight design of infrared sensors but also paves the way for the creation of innovative new form-factor products that were previously unimaginable. Moreover, by reducing the massive energy consumption associated with high-temperature processes, this approach can lower production costs and enable eco-friendly manufacturing—contributing to the sustainable development of the infrared sensor industry.” The research results were published online in Nature Communications on October 16, 2025, under the title “Ligand-exchange-assisted printing of colloidal nanocrystals to enable all-printed sub-micron optoelectronics” (DOI: https://doi.org/10.1038/s41467-025-64596-4). This research was supported by the Ministry of Science and ICT of Korea through the Excellent Young Researcher Program (RS−2025−00556379), the National Strategic Technology Material Development Program (RS−2024−00407084), and the International Cooperation Research Program for Original Technology Development (RS−2024−00438059).  

“AI,” the New Language of Materials Science and En..

<(From Left)  M.S candidate Chaeyul Kang, Professor Seumgbum Hong, Ph. D candidate Benediktus Madika, Ph.D candidate Batzorig Buyantogtokh, Ph.D candiate Aditi Saha, > Collaborating authors include Professor Joshua Agar (Drexel University), Professors Chris Wolverton and Peter Voorhees (Northwestern University), Professor Peter Littlewood (University of St Andrews), and Professor Sergei Kalinin (University of Tennessee). Paper Title: Artificial Intelligence for Materials Discovery, Development, and Optimization The era has arrived in which artificial intelligence (AI) autonomously imagines and predicts the structures and properties of new materials. Today, AI functions as a researcher’s “second brain,” actively participating in every stage of research, from idea generation to experimental validation. KAIST (President Kwang Hyung Lee) announced on October 26 that a comprehensive review paper analyzing the impact of AI, Machine Learning (ML), and Deep Learning (DL) technologies across materials science and engineering has been published in ACS Nano (Impact Factor = 18.7). The paper was co-authored by Professor Seungbum Hong and his team from the Department of Materials Science and Engineering at KAIST, in collaboration with researchers from Drexel University, Northwestern University, the University of St Andrews, and the University of Tennessee in the United States. The research team proposed a full-cycle utilization strategy for materials innovation through an AI-based catalyst search platform, which embodies the concept of a Self-Driving Lab—a system in which robots autonomously perform materials synthesis and optimization experiments. Professor Hong’s team categorized materials research into three major stages—Discovery, Development, and Optimization—and detailed the distinctive role of AI in each phase: In the Discovery Stage, AI designs new structures, predicts properties, and rapidly identifies the most promising materials among vast candidate pools. In the Development Stage, AI analyzes experimental data and autonomously adjusts experimental processes through Self-Driving Lab systems, significantly shortening research timelines. In the Optimization Stage, AI employs Reinforcement Learning, which identifies optimal conditions through Bayesian Optimization, which efficiently finds superior results with minimal experimentation, to fine-tune designs and process conditions for maximum performance. In essence, AI serves as a “smart assistant” that narrows down the most promising materials, reduces experimental trial and error, and autonomously optimizes experimental conditions to achieve the best-performing outcomes. The paper further highlights how cutting-edge technologies such as Generative AI, Graph Neural Networks (GNNs), and Transformer models are transforming AI from a computational tool into a “thinking researcher.” Nonetheless, the team cautions that AI’s predictions are not error-proof and that key challenges persist, such as imbalanced data quality, limited interpretability of AI predictions, and integration of heterogeneous datasets. To address these limitations, the authors emphasize the importance of developing AI systems capable of autonomously understanding physical principles and ensuring transparent, verifiable decision-making processes for researchers. The review also explores the concept of the Self-Driving Lab, where AI autonomously designs experimental plans, analyzes results, and determines the next experimental steps—without manual operation by researchers. The AI-Based Catalyst Search Platform exemplifies this concept, enabling robots to automatically design, execute, and optimize catalyst synthesis experiments. In particular, the study presents cases in which AI-driven experimentation has dramatically accelerated catalyst development, suggesting that similar approaches could revolutionize research in battery and energy materials. <AI Driving Innovation Across the Entire Cycle of New Material Discovery, Development, and Optimization> “This review demonstrates that artificial intelligence is emerging as the new language of materials science and engineering, transcending its role as a mere tool,” said Professor Seungbum Hong. “The roadmap presented by the KAIST team will serve as a valuable guide for researchers in Korea’s national core industries including batteries, semiconductors, and energy materials.” Benediktus Madika (Ph.D. candidate), Aditi Saha (Ph.D. candidate), Chaeyul Kang (M.S. candidate), and Batzorig Buyantogtokh (Ph.D. candidate) from KAIST’s Department of Materials Science and Engineering contributed as co-first authors. Collaborating authors include Professor Joshua Agar (Drexel University), Professors Chris Wolverton and Peter Voorhees (Northwestern University), Professor Peter Littlewood (University of St Andrews), and Professor Sergei Kalinin (University of Tennessee). Paper Title: Artificial Intelligence for Materials Discovery, Development, and Optimization DOI: 10.1021/acsnano.5c04200 This work was supported by the National Research Foundation of Korea (NRF) with funding from the Ministry of Science and ICT (RS-2023-00247245).

KAIST, Dancing Like ＇Navillera＇... AI Understands ..

<(From Left)Ph.D candidate Jihyun Lee, Professor Tae-Kyun Kim, M.S candidate Changmin Lee> The era has begun where AI moves beyond merely 'plausibly drawing' to understanding even why clothes flutter and wrinkles form. A KAIST research team has developed a new generative AI that learns movement and interaction in 3D space following physical laws. This technology, which overcomes the limitations of existing 2D-based video AI, is expected to enhance the realism of avatars in films, the metaverse, and games, and significantly reduce the need for motion capture or manual 3D graphics work. KAIST (President Kwang Hyung Lee) announced on the 22nd that the research team of Professor Tae-Kyun (T-K) Kim from the School of Computing has developed 'MPMAvatar,' a spatial and physics-based generative AI model that overcomes the limitations of existing 2D pixel-based video generation technology. To solve the problems of conventional 2D technology, the research team proposed a new method that reconstructs multi-view images into 3D space using Gaussian Splatting and combines it with the Material Point Method (MPM), a physics simulation technique. In other words, the AI was trained to learn physical laws on its own by stereoscopically reconstructing videos taken from multiple viewpoints and allowing objects within that space to move and interact as if they were in real physical world. This enables the AI to compute the movement based on objects' material, shape, and external forces, and then learn the physical laws by comparing the results with actual videos. The research team represented the 3D space using point-units, and by applying both Gaussian and MPM to each point, they simultaneously achieved physically natural movement and realistic video rendering. That is, they divided the 3D space into numerous small points, making each point move and deform like a real object, thereby realizing natural video that is nearly indistinguishable from reality. In particular, to precisely express the interaction of thin and complex objects like clothing, they calculated both the object's surface (mesh) and its particle-unit structure (point), and utilized the Material Point Method (MPM), which calculates the object's movement and deformation in 3D space according to physical laws. Furthermore, they developed a new collision handling technology to realistically reproduce scenes where clothes or objects move and collide with each other in multiple spots and complex manner. The generative AI model MPMAvatar, to which this technology is applied, successfully reproduced the realistic movement and interaction of a person wearing loose clothing, and also succeeded in 'Zero-shot' generation, where the AI processes data it has never seen during the learning process by inferring on its own. <Figure 1. Modeling new human poses and clothing dynamics from multi-view video input, and zero-shot generation of novel physical interactions.> The proposed method is applicable to various physical properties, such as rigid bodies, deformable objects, and fluids, allowing it to be used not only for avatars but also for the generation of general complex scenes. <“Figure 2. Depiction of graceful dance movements and soft clothing folds, like Navillera.> Professor Tae-Kyun (T-K) Kim explained, "This technology goes beyond AI simply drawing a picture; it makes the AI understand 'why' the world in front of it looks the way it does. This research demonstrates the potential of 'Physical AI' that understands and predicts physical laws, marking an important turning point toward AGI (Artificial General Intelligence)." He added, "It is expected to be practically applied across the broaden immersive content industry, including virtual production, films, short-form contents, and adverts, creating significant change." The research team is currently expanding this technology to develop a model that can generate physically consistent 3D videos simply from a user's text input. This research involved Changmin Lee, a Master's student at the KAIST Graduate School of AI, as the first author, and Jihyun Lee, a Ph.D. student at the KAIST School of Computing, as a co-author. The research results will be presented at NeurIPS, the most prestigious international academic conference in the field of AI, on December 2nd, and the program code is to be fully released. ·         Paper: C. Lee, J. Lee, T-K. Kim, MPMAvatar: Learning 3D Gaussian Avatars with Accurate and Robust Physics-Based Dynamics, Proc. of Thirty-Ninth Annual Conf. on Neural Information Processing Systems (NeurIPS), San Diego, US, 2025 ·         arXiv version: https://arxiv.org/abs/2510.01619 ·         Related Project Site: https://kaistchangmin.github.io/MPMAvatar/ ·         Related video links showing the 'Navillera'-like dancing drawn by AI: o    https://www.youtube.com/shorts/ZE2KoRvUF5c o    https://youtu.be/ytrKDNqACqM This work was supported by the Institute of Information & Communications Technology Planning & Evaluation(IITP) grant funded by the Korea government(MSIT) through the Human-Oriented Next-Generation Challenging General AI Technology Development Project (RS-2025-25443318) and the Professional AI Talent Development Program for Multimodal AI Agents (RS-2025-25441313).

Refrigerator Use Increases with Stress, IoT Sensor..

<(From Left) Ph.D candidate Chanhee Lee, Professor Uichin Lee, Professor Hyunsoo Lee, Ph.D candidate Youngji Koh from School of Computing> The number of single-person households in South Korea has exceeded 8 million, accounting for 36％ of the total, marking an all-time high. A Seoul Metropolitan Government survey found that 62％ of single-person households experience 'loneliness', deepening feelings of isolation and mental health issues. KAIST researchers have gone beyond the limitations of smartphones and wearables, utilizing in-home IoT data to reveal that a disruption in daily rhythm is a key indicator of worsening mental health. This research is expected to lay the foundation for developing personalized mental healthcare management systems. KAIST (President Kwang Hyung Lee) announced on the 21st of October that a research team led by Professor Uichin Lee from the School of Computing has demonstrated the possibility of accurately tracking an individual's mental health status using in-home Internet of Things (IoT) sensor data. Consistent self-monitoring is important for mental health management, but existing smartphone- or wearable-based tracking methods have the limitation of data loss when the user is not wearing or carrying the device inside the home. The research team therefore focused on in-home environmental data. A 4-week pilot study was conducted on 20 young single-person households, installing appliances, sleep mats, motion sensors, and other devices to collect IoT data, which was then analyzed along with smartphone and wearable data. The results confirmed that utilizing IoT data alongside existing methods allows for a significantly more accurate capture of changes in mental health. For instance, reduced sleep time was closely linked to increased levels of depression, anxiety, and stress, and increased indoor temperature also showed a correlation with anxiety and depression. <Picture1. Heatmap of the Correlation Between Each User’s Mental Health Status and Sensor Data> Participants' behavioral patterns varied, including a 'binge-eating type' with increased refrigerator use during stress and a 'lethargic type' with a sharp decrease in activity. However, a common trend clearly emerged: mental health deteriorated as daily routines became more irregular. Variability in daily patterns was confirmed to be a more important factor than the frequency of specific behaviors, suggesting that a regular routine is essential for maintaining mental health. When research participants viewed their life data through visualization software, they generally perceived the data as being genuinely helpful in understanding their mental health, rather than expressing concern about privacy invasion. This significantly enhanced the research acceptance and satisfaction with participation. <Figure 2. Comparison of Average Mental Health Status Between the High Irregularity Group (Red) and the Low Irregularity Group (Blue)>

KAIST Develops Ultrafast Photothermal Process Achi..

<< (from left) Ph.D. candidate Seo-Hak Park, Dr. Jae-Wan Ahn, Ph.D. candidate Do-Kyung Jeon, Prof. Sung-Yul Choi, Prof. Il-Doo Kim, Dr. Chung-Sung Park, Ph.D. candidate Ui-Chul Shin (top left) Dr. Ha-Min Shin, Dr. Jun-Hoe Choi >> The rapid and energy-efficient synthesis of high-performance catalysts is a critical hurdle in advancing clean energy technologies like hydrogen production. Addressing this challenge, a research team at KAIST has now developed a novel platform technology that utilizes a 0.02-second flash of light to generate an ultrahigh temperature of 3,000 °C, enabling the highly efficient synthesis of catalysts. This breakthrough process reduces energy consumption by more than a thousandfold compared to conventional methods while increasing hydrogen production efficiency by up to six times, marking a significant step toward the commercialization of clean energy. KAIST (President Kwang Hyung Lee) announced on October 20 that a joint research team, co-led by Professor Il-Doo Kim from the Department of Materials Science and Engineering and Professor Sung-Yool Choi from the School of Electrical Engineering, has developed a “direct-contact photothermal annealing” platform. This technique synthesizes high-performance nanomaterials through brief exposure to intense light, generating a transient temperature of 3,000 °C in just 0.02 seconds. Using this intense photothermal energy, the researchers successfully converted chemically inert nanodiamond (ND) precursors into highly conductive and catalytically active carbon nanoonions (CNOs). More impressively, the method simultaneously functionalizes the surface of the newly formed CNOs with single atoms. This integrated, one-step process restructures the support material and embeds catalytic functionality in a single light pulse, representing a significant innovation in catalyst synthesis. CNOs, composed of concentric graphitic shells, are ideal catalyst supports due to their high conductivity, large specific surface area, and chemical stability. However, traditional CNO synthesis has been hindered by complex, multi-step post-processing required to load metal catalysts and by reliance on energy-intensive, time-consuming thermal treatments that limit scalability. < Schematic Illustration of the Limitations of Conventional Thermal-Radiation Synthesis and the Carbon Nano-Onion Conversion via Direct-Contact Photothermal Treatment > To overcome these limitations, the KAIST team leveraged the photothermal effect. They devised a method of mixing ND precursors with light-absorbing carbon black (CB) and applying an intense pulse from a xenon lamp. This approach triggers the transformation of NDs into CNOs in just 0.02 seconds, a phenomenon validated by molecular dynamics simulations. A key innovation of this platform is the simultaneous synthesis of CNOs and functionalization of single-atom catalysts (SACs). When metal precursors, such as platinum (Pt), are included in the mixture, they decompose and anchor onto the surface of the nascent CNOs as individual atoms. The subsequent rapid cooling prevents atomic aggregation, resulting in a perfectly integrated one-step process for both synthesis and functionalization. The team has successfully synthesized eight different high-density SACs, including platinum (Pt), cobalt (Co), and nickel (Ni). The resulting Pt-CNO demonstrated a sixfold enhancement in hydrogen evolution efficiency compared to conventional catalysts, achieving high performance with significantly smaller quantities of precious metals. This highlights the technology's potential for scalable and sustainable hydrogen production. “We have developed, for the first time, a direct-contact photothermal annealing process that reaches 3,000°C in under 0.02 seconds,” said Professor Il-Doo Kim. “This ultrafast synthesis and single-atom functionalization platform reduces energy consumption by more than a thousandfold compared to traditional methods. We expect it to accelerate the commercialization of technologies in hydrogen energy, gas sensing, and environmental catalysis.” The study’s first authors are Dogyeong Jeon (Ph.D. candidate, Department of Materials Science and Engineering, KAIST), Dr. Hamin Shin (an alumnus of the Department of Materials Science and Engineering and a current postdoctoral researcher at ETH Zurich), and Dr. Jun-Hwe Cha (an alumnus of the School of Electrical Engineering, now at SK hynix). Professors Sung-Yool Choi and Il-Doo Kim are the corresponding authors.＼ < Inside Cover Image of the September Issue of ACS > The research was published as a Supplementary Cover Article in the September issue of ACS Nano, a leading international journal of the American Chemical Society (ACS). ※ Paper title: “Photothermal Annealing-Enabled Millisecond Synthesis of Carbon Nanoonions and Simultaneous Single-Atom Functionalization,” DOI: 10.1021/acsnano.5c11229 This research was supported by the Global R&D Infrastructure Program and the Leading Research Center Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, and the Nano Convergence Technology Center’s Semiconductor–Battery Interfacing Platform Development Project.    

KAIST Develops AI Technology That Predicts and Ass..

<(From left) Dr. Younghyun Han, (top center) Dr. Chun-Kyung Lee, (bottom center) Prof. Kwang-Hyun Cho,Ph.D. candidate Hyunjin Kim> Controlling the state of a cell in a desired direction is one of the central challenges in life sciences, including drug development, cancer treatment, and regenerative medicine. However, identifying the right drug or genetic target for that purpose is extremely difficult. To address this, researchers at KAIST have mathematically modeled the interaction between cells and drugs in a modular “Lego block” manner—breaking them down and recombining them—to develop a new AI technology that can predict not only new cell–drug reactions never before tested but also the effects of arbitrary genetic perturbations. KAIST (President Kwang Hyung Lee) announced on the 16th of October that a research team led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering has developed a generative AI-based technology capable of identifying drugs and genetic targets that can guide cells toward a desired state. “Latent space” is an invisible mathematical map used by image-generating AI to organize the essential features of objects or cells. The research team succeeded in separating the representations of cell states and drug effects within this space and then recombining them to predict the reactions of previously untested cell–drug combinations. They further extended this principle to show that the model can also predict how a cell’s state would change when a specific gene is regulated. The team validated this approach using real experimental data. As a result, the AI identified molecular targets capable of reverting colorectal cancer cells toward a normal-like state, which the team later confirmed through cell experiments. This finding demonstrates that the method is not limited to cancer treatment—it serves as a general platform capable of predicting various untrained cell-state transitions and drug responses. In other words, the technology not only determines whether or not a drug works but also reveals how it functions inside the cell, making the achievement particularly meaningful. <Latent Space Direction Vector–Based Cell Transition Modeling> The research provides a powerful tool for designing methods to induce desired cell-state changes. It is expected to have broad applications in drug discovery, cancer therapy, and regenerative medicine, such as restoring damaged cells to a healthy state. Professor Kwang-Hyun Cho stated, “Inspired by image-generation AI, we applied the concept of a ‘direction vector,’ an idea that allows us to transform cells in a desired direction.” He added, “This technology enables quantitative analysis of how specific drugs or genes affect cells and even predicts previously unknown reactions, making it a highly generalizable AI framework.” The study was conducted with Dr. Younghyun Han, Ph.D. candidate Hyunjin Kim, and Dr. Chun-Kyung Lee of KAIST. The research findings were published online in Cell Systems, a journal by Cell Press, on October 15.  ※ Paper title: “Identifying an Optimal Perturbation to Induce a Desired Cell State by Generative Deep Learning” (DOI: 10.1016/j.cels.2025.101405) The study was supported by the National Research Foundation of Korea (NRF) through the Ministry of Science and ICT’s Mid-Career Researcher Program and the Basic Research Laboratory (BRL) Program.